[4-(Chloromethyl)phenyl]methanol → HCID 23159969, compound

HRID 2110858Notes

Reaction equation

HRID 2110858 reaction equation
[CH:1]([C:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:6][N:5]=1)([CH3:3])[CH3:2].Cl[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=1>>[CH:1]([C:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:6]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 5107660[4-(Chloromethyl)phenyl]methanolHCID 178438779HCID 178438779, compound

Product 1

HCID 23159969HCID 23159969, compoundYield 9%

Procedure

In the same manner as in Reference Example 41, the title compound (285 mg, yield 9%) was obtained as a colorless oil from 3-isopropyl-5-phenyl-1H-pyrazole and [4-(chloromethyl)phenyl]methanol. 1H NMR (CDCl3) δ: 1.32 (6H, d, J=7.0 Hz), 1.64 (1H, t, J=5.8 Hz), 2.99-3.09 (1H, m), 4.66 (2H, d, J=5.8 Hz), 5.30 (2H, s), 6.18 (1H, s), 6.97-7.06 (2H, m), 7.24-7.39 (7H, m).

Sources & evidence

ORD record
ord-bdc6d90b01a94dd6a463e2e8bada5810
Source dataset
uspto-grants-2009_04
Patent number
US07517910B2

Reaction notes

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