2-Chloroethyl isocyanate → HCID 11736224, compound

HRID 2110917Notes

Reaction equation

HRID 2110917 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[Cl:10][CH2:11][CH2:12][N:13]=[C:14]=[O:15]>O1CCOCC1>[Cl:10][CH2:11][CH2:12][NH:13][C:14]([NH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[CH:3]=1)=[O:15]

Participants

4

Reactant 2

HCID 160352-Chloroethyl isocyanateHCID 167023-Aminobenzonitrile

Product 1

HCID 11736224HCID 11736224, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

65.00 g (550 mmol) 3-amino-benzonitrile are dissolved in 450 ml dioxane, 56 ml (660 mmol) 1-chloro-2-isocyanato-ethane dissolved in 60 ml dioxane are added dropwise. The reaction mixture is stirred for 3 hours at 60° C. and for 16 hours at ambient temperature. Then the precipitate is suction filtered, washed with diethyl ether and dried.

Workup

  1. additionare added dropwise
  2. filtrationfiltered
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-b23faa61ac3245e0bbf4523945448374
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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