Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate → 2-(5-Ethyloxazol-2-yl)ethylamine

HRID 2110925Notes

Reaction equation

HRID 2110925 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]1[O:14][C:15]([CH2:18][CH3:19])=[CH:16][N:17]=1)C1C=CC=CC=1>CO.[Pd]>[CH2:18]([C:15]1[O:14][C:13]([CH2:12][CH2:11][NH2:10])=[N:17][CH:16]=1)[CH3:19]

Participants

4

Reactant 1

HCID 57636953Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate

Product 1

HCID 115428012-(5-Ethyloxazol-2-yl)ethylamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.86 g (10.43 mmol) benzyl[2-(5-ethyl-oxazol-2-yl)-ethyl]-carbamate are placed in 130 ml of methanol, 0.910 mg palladium/charcoal 10% are added, then the mixture is hydrogenated for 5 hours at ambient temperature under a pressure of 14 psi. Then the catalyst is removed by suction filtering, and the solution is evaporated down.

Workup

  1. customThen the catalyst is removed by suction
  2. filtrationfiltering
  3. customthe solution is evaporated down

Sources & evidence

ORD record
ord-970def94f43741bfb7cbc2e14f609c7c
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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