Hydrochloric Acid → HCID 44441080, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (1 ml) of methyl 3-(4-[4-[1-(2-chlorophenyl)ethoxy-carbonylamino]-5-isoxazolyl]benzylsulfanyl)propionate (22 mg, 0.046 mmol) in ethanol was added 2N hydrochloric acid (2 ml), and the mixture was stirred at 50° C. for 4 hours. The solvent was evaporated under reduced pressure, and water was added. The mixture was extracted with ethyl acetate, and the extract was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained crude product was purified by silica gel chromatography (dichloromethane:methanol=9:1) to give the title compound (10 mg, 47%).

Provenance & Evidence