Hydrochloric Acid → HCID 11271434, compound

Participants

Reaction Steps

(2R)-2-Acetoxy-4-[(4-{4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-isoxazolyl}phenyl)amino]-4-oxobutanoic acid (132 mg, 0.256 mmol) was dissolved in methanol (2.5 ml), 1N aqueous sodium hydroxide solution (2.5 ml) was added, and the mixture was stirred at room temperature for 1 hour. 1N Hydrochloric acid (2.6 ml) was added at 0° C. to weak-acidify the reaction system, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (111 mg, 92%).

Provenance & Evidence