HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2111042Generated: November 2, 2026
Hydrochloric Acid → Sertraline Hydrochloride
https://huagongshe.com/reaction/2111042
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Isoamyl Alcohol | HCID 31260 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Sertraline free base (residue, 5 gm) is dissolved in isoamyl alcohol (35 ml) at 25-30° C., pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25-30° C. and then stirred for 14 hours at 25-30° C. Filtered the solid and dried at 65° C. for 4 hours to give 2.4 gm of sertraline hydrochloride crystalline form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07518019B2 |
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| Source dataset | uspto-grants-2009_04 |
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| ORD ID | ord-6d6c28095fd54ed4b0bd8a2abd28e087 |
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| Source note | uspto-grants-2009_04 |
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