HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2111046Generated: November 1, 2026
Hydrochloric Acid → Sertraline Hydrochloride
https://huagongshe.com/reaction/2111046
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isoamyl Alcohol | HCID 31260 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Isoamyl alcohol (30 ml) and ethyl acetate (30 ml) are added to sertraline free base (10 gm) under stirring at 25-30° C., pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25-30° C. and then stirred for 4 hours 15 minutes at 25-30° C. Filtered the solid and dried for 7 hours at 60° C. to give 7.4 gm of sertraline hydrochloride crystalline form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07518019B2 |
|---|
| Source dataset | uspto-grants-2009_04 |
|---|
| ORD ID | ord-01575652c8b24072930fc2ce7cd97610 |
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| Source note | uspto-grants-2009_04 |
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