O-Methylhydroxylamine → 2-(2-Fluoro-4-iodophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methoxyamide

HRID 2111096Notes

Reaction equation

HRID 2111096 reaction equation
CO[C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH3:12])[C:6]=1[NH:13][C:14]1[CH:19]=[CH:18][C:17]([I:20])=[CH:16][C:15]=1[F:21])=[O:4].[CH3:22][O:23][NH2:24]>>[CH3:22][O:23][NH:24][C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH3:12])[C:6]=1[NH:13][C:14]1[CH:19]=[CH:18][C:17]([I:20])=[CH:16][C:15]=1[F:21])=[O:4]

Participants

3

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 666742482-(2-Fluoro-4-iodophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester

Product 1

HCID 117504162-(2-Fluoro-4-iodophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methoxyamide

Procedure

2-(2-Fluoro-4-iodophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester was coupled as described previously in Example 155 using O-methyl-hydroxylamine. MS ESI (+) m/z 418 (M+1) detected.

Sources & evidence

ORD record
ord-05d75bd1fffb4759838b4fb27ae0e465
Source dataset
uspto-grants-2009_04
Patent number
US07517994B2

Reaction notes

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