Diphenylmethylidenehydrazine → HCID 76571888, compound

Participants

Reaction Conditions

Reaction Steps

To 3-bromo-5-dimethylaminomethyl-thiophene-2-carbaldehyde [4.30 g, 17.3 mmol, Intermediate (2)] in ethanol (40 mL) is added benzophenone hydrazone (3.75 g, 19.0 mmol). The solution was heated at 65° C. for 5 hours. The solvent is removed under reduced pressure. The residue is chromatographed through silica gel (n-heptane-ethyl acetate. 90:10 as eluant) to produce [5-(Benzhydrylidene-hydrazonomethyl)-4-bromo-thiophen-2-ylmethyl]-dimethyl-amine] 5.57 g, 75%, Intermediate (3)] as an orange oil. LC/MS: RT=2.72 minutes, 426.05 m/e (M+H).

Provenance & Evidence