Ethyl 1-cyanocyclopropanecarboxylate → Methyl 1-(aminomethyl)cyclopropanecarboxylate

HRID 2111262Notes

Reaction equation

HRID 2111262 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]#[N:10])[CH2:8][CH2:7]1)=[O:5])C.COC(=O)C(C)(C)CN>>[CH3:1][O:3][C:4]([C:6]1([CH2:9][NH2:10])[CH2:8][CH2:7]1)=[O:5]

Participants

3

Reactant 2

HCID 380810Ethyl 1-cyanocyclopropanecarboxylateHCID 13285789Methyl 3-amino-2,2-dimethylpropanoate

Product 1

HCID 21464885Methyl 1-(aminomethyl)cyclopropanecarboxylate

Procedure

1-aminomethyl-cyclopropanecarboxylic acid methyl ester was prepared by hydrogenation of 1-cyano-cyclopropanecarboxylic acid ethyl ester, by the method similar to the preparation of 3-amino-2,2-dimethyl-propanoic acid methyl ester, above.

Sources & evidence

ORD record
ord-b32d8ae54e434254bd01164151f55ba7
Source dataset
uspto-grants-2009_04
Patent number
US07517873B2

Reaction notes

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