Carbonate Ion → HCID 57635045, compound

Participants

Reaction Steps

To a suspension of 0.045 g of (rac)-4-(9-cyclohexyl-7-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide trifluoro-acetic acid salt in tetrahydrofuran was added 0.2 g of SilicaBond Carbonate (Silicycle). The mixture was stirred at room temperature for 3 hours, then filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with dichloromethane-methanol (100:0-75:25) to give 0.020 g of (rac)-4-(9-cyclohexyl-7-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide (I-18) as a white powder. HRMS (ES+) m/z Calcd for C28H39N7O3+H [(M+H)+]: 522.3187. Found: 522.3187.

Provenance & Evidence