Dimethylformamide → 2-Chloro-9-cyclohexyl-5-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

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Reaction Steps

A mixture of 0.12 g (0.00042 mole) of 2-chloro-9-cyclohexyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one (VI-20), 0.469 g (0.00144 mole) of cesium carbonate, 0.135 g (0.00096 mole) of iodomethane and 1 mL of dimethylformamide was stirred overnight at ambient temperature and then diluted with 5 mL of water. The mixture was stirred for 15 minutes and the solid was collected by filtration to give 2-chloro-9-cyclohexyl-5-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one (VII-20) which was used without further purification.

Provenance & Evidence