Water → HCID 86623408, compound

Participants

Reaction Steps

A mixture of 0.127 g (0.0005 mole) of 2-chloro-9-cyclobutyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one (VI-23), 0.442 g (0.0014 mole) of cesium carbonate and 0.13 g (0.0009 mole) of iodomethane in 1 mL of dimethylformamide was stirred overnight at ambient temperature and then 2 mL of water was added and the mixture stirred for an additional 10 minutes. A solid formed, which was collected by filtration, to give 2-chloro-9-cyclobutyl-5-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one (VII-23), which was used directly in the next step.

Provenance & Evidence