Trifluoroacetic acid → HCID 87555139, compound

Participants

Reaction Steps

To an ice cooled mixture of 1 g (0.0032 mole) of (rac)-1-(2-chloro-5-nitro-pyrimidin-4-yl)-piperidine-3-carboxylic acid ethyl ester (IV-67), 1.96 mL of trifluoracetic acid and 15 mL of ethyl acetate, was added 2.76 g (0.02 mole) of stannous chloride dihydrate. The mixture was stirred overnight at ambient temperature. The mixture was made basic (pH 14) by the addition of 15% sodium hydroxide solution. The mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 0.086 g of (rac)-1-(5-amino-2-chloro-pyrimidin-4-yl)-piperidine-3-carboxylic acid ethyl ester (V-67).

Provenance & Evidence