Ethanol → HCID 87577134, compound

HRID 2111430Notes

Reaction equation

HRID 2111430 reaction equation
[CH2:1]([OH:3])[CH3:2].COC([CH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[N:13]([C:19]1[C:24]([NH2:25])=[CH:23][N:22]=[C:21]([Cl:26])[N:20]=1)[CH:14]1C[CH2:17][CH2:16][CH2:15]1)=O>C(O)(=O)C>[Cl:26][C:21]1[N:22]=[CH:23][C:24]2[NH:25][C:1](=[O:3])[CH:2]3[CH:14]([CH2:15][CH2:16][CH2:17]3)[N:13]([CH:9]3[CH2:10][CH2:11][CH2:12][CH2:8]3)[C:19]=2[N:20]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 87555518HCID 87555518, compound

Product 1

HCID 87577134HCID 87577134, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 150 mL of ethanol, 3.0 mL of acetic acid and 2.85 g (0.0084 mole) of (rac)-2-[(5-amino-2-chloro-pyrimidin-4-yl)-cyclopentyl-amino]-cyclopentanecarboxylic acid methyl ester (V-68) from the previous step, combined with material from a separate experiment was heated at reflux overnight and then concentrated under reduced pressure to give 2.49 g of (rac)-6-chloro-4-cyclopentyl-2,3,3a,4,9,10a-hexahydro-1H-4,5,7,9-tetraaza-benzo[f]azulen-10-one (VI-68), which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-10933227ed4843619c7454e86e055ed1
Source dataset
uspto-grants-2009_04
Patent number
US07517873B2

Reaction notes

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