Ammonium Chloride → HCID 11749117, compound

Participants

Reaction Steps

2-(4-Ethylbenzyl)aniline 1 (500 mg) was dissolved in methanol (5 ml), and thereto are added D-(+)-glucose 2 (516 mg) and ammonium chloride (25 mg), and the mixture was heated under reflux for 2 hours. Methanol was evaporated under reduced pressure, and water was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (chloroform:methanol=40:1-20:1) to give the desired 2-(4-ethylbenzyl)-N-(β-D-glucopyranosyl)aniline 3 (495 mg) as colorless crystals. APCI-Mass m/Z 374 (M+H).

Provenance & Evidence