N-Carbobenzoxy-L-valine → HCID 86608595, compound

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Reaction Steps

Cbz-Val-Phe-VS-Ph was prepared from Cbz-Val-OH and Phe-VS-Ph.HCl using standard mixed anhydride coupling method, yield 98%. 1H-NMR (CDCl3) δ 0.70-0.84 (2d, 6H, Val-CH3), 2.06 (m, 1H, Val-CH), 2.91 (m, 2H, CH2-Phe), 3.82 (m, 1H, α-H), 4.80-4.90 (m, 1H, α-H), 5.10 (s, 2H, Cbz), 5.96 (d, 1H, NH) 6.34 (d, 1H, CH═), 6.9-7.0 (dd, 1H, CH═), 7.1-7.4 (m, 10H, 2×Ph), 7.5-7.7 (m, 5H, SO2-Ph). MS (ESI) m/z 521 (M+1, 100%).

Provenance & Evidence