HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromotoluene → 1-Benzyl-4-(4-methylphenyl)piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromotoluene | HCID 7805 | — |
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-4-(4-methylphenyl)piperidin-4-ol | HCID 198608 | 92.8% |
Reaction Steps
This compound is prepared according to procedure described in step A) of Preparation 8.3, starting with 2.6 g of magnesium in 15 ml of THF, 15 g of 1-bromo-4-methylbenzene in 100 ml of THF and 16.6 g of 1-benzyl-4-piperidinone in 100 ml of THF. 22.9 g of the expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07521449B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-7fe8e0a5383f4b2b8dc5127f6f85b032 |
| Source note | uspto-grants-2009_04 |