HCID 68917014, compound → HCID 23084556, compound

HRID 2111631Notes

Reaction equation

HRID 2111631 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[CH3:11])[C:7](=[O:12])[N:6]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1)[C:5]2=[CH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>C(O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[CH3:11])[C:7](=[O:12])[N:6]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1)[CH:5]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

Participants

4

Reactant 1

HCID 68917014HCID 68917014, compound

Product 1

HCID 23084556HCID 23084556, compoundYield 23%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of the product of above-mentioned (10-b) (88 mg, 0.27 mmol) in ethanol (10 ml) was added 18 mg of 10% palladium on carbon, and stirred vigorously under a hydrogen atmosphere at 25° C. for 2 hrs. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform:acetone=5:1) to give 20 mg of the title compound.

Workup

  1. filtrationThe reaction solution was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was purified by silica gel chromatography (chloroform:acetone=5:1)

Sources & evidence

ORD record
ord-86bf6be09f7a477e92df3a22b6a99d0a
Source dataset
uspto-grants-2009_04
Patent number
US07521451B2

Reaction notes

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