反应详情

Stir a solution of trans-2-(4-methyl-cyclohexylcarbamoyl)-cyclopropane-carboxylic acid monomethyl ester (Example 11a) (4.5 g, 19.8 mmol), 5N NaOH (40 mL) and MeOH/dioxane overnight. Concentrate the reaction mixture under vacuum, cool the resulting solution and acidify to pH 5. Collect the precipitate, wash (H2O) and dry under vacuum at 40° C. to obtain 3.7 g (87%) of solid.

1. concentrationConcentrate the reaction mixture under vacuum
2. temperaturecool the resulting solution
3. customCollect the precipitate
4. washwash (H2O)
5. customdry under vacuum at 40° C.