m-Chloroperbenzoic acid → HCID 11444006, compound

Participants

Reaction Steps

N-Pyridin-3-ylmethyl-1-(4-{[4-(trifluoromethoxy)benzyl]oxy}phenyl)-1H-benzimidazole-5-carboxamide (EXAMPLE 35, 31 mg, 0.060 mmol) was dissolved in DCM (3 mL) and treated with m-chloroperoxybenzoic acid (18 mg, 0.72 mmol) and the mixture stirred at rt for 4 h. After this time the mixture was concentrated in vacuo and the crude product purified by preparative HPLC to give the title compound. 1H NMR (CD3OD, 400 MHz): δ 4.63 (s, 2H), 5.21 (s, 2H), 7.24 (d, 2H, J=9.2 Hz), 7.31 (d, 2H, J=8.4 Hz), 7.51-7.60 (m, 6H), 7.66 (d, 1H, J=8.0 Hz), 7.90 (dd, 1H, J=8.8, 1.6 Hz), 8.25 (d, 1H, J=6.0 Hz), 8.31 (s, 1H), 8.38 (s, 1H), 8.46 (s, 1H). MS (ES+); m/z 535 (100) [MH+], 536 (25) [MH+2].

Provenance & Evidence