HCID 69070759, compound → HCID 69067477, compound

Participants

Reaction Steps

A solution of 1-[3-(acetylamino)phenyl]-N-(pyridin-3-ylmethyl)-1H-benzimidazole-5-carboxamide (0.47 g) in 2M HCl(aq) (5 mL) was heated at reflux until complete consumption of the starting material as judged by LC-MS (approximately 40 min). The crude reaction mixture was concentrated in vacuo and the residue dried in vacuo to afford 1-(3-aminophenyl)-N-(pyridin-3-ylmethyl)-1H-benzimidazole-5-carboxamide that was used without further purification. 1H-NMR (DMSO-d6, 400 MHz): δ 3.5-5.5 (br), 4.72 (d, J=5.2 Hz, 2H), 7.24 (d, J=7.6 Hz, 1H), 7.39 (d, J=7.6 Hz, 1H), 7.44 (s, 1H), 7.56 (t, J=8.4 Hz, 1H), 7.82 (d, J=8.4 Hz, 1H), 8.10-8.50 (m, 2H), 8.47 (s, 1H), 8.59 (d, J=8.0 Hz, 1H), 8.85 (1H, J=5.6 Hz, 1H), 8.96 (s, 1H), 9.25 (s, 1H), 9.64 (t, J=5.6 Hz, 1H). MS (ES+): m/z 344 [MH+]

Provenance & Evidence