4-Nitrophenol → 4-[3-(Pyrrolidin-1-yl)propoxy]aniline

HRID 2111822Notes

Reaction equation

[N:1]1([CH2:6][CH2:7][CH2:8][OH:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N+:10]([C:13]1[CH:18]=[CH:17][C:16](O)=[CH:15][CH:14]=1)([O-])=O.FC1C=CC([N+]([O-])=O)=CC=1>>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:16]2[CH:17]=[CH:18][C:13]([NH2:10])=[CH:14][CH:15]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 3

HCID 9804-Nitrophenol

HCID 9590p-Fluoronitrobenzene

HCID 2093421-Pyrrolidinepropanol

Product 1

HCID 129353854-[3-(Pyrrolidin-1-yl)propoxy]aniline

Procedure

The target compound was obtained by the method according to Example 18, using 3-pyrrolidin-1-yl-propan-1-ol, and 4-nitrophenol or 1-fluoro-4-nitrobenzene as starting materials.

Workup

customThe target compound was obtained by the method

Sources & evidence

ORD record: ord-2f94b74bcef54e28af2c97020a4fbc50
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07521455B2

Reaction notes

Loading…