N-benzyl-3-pyrrolidinol → HCID 23151307, compound

HRID 2111839Notes

Reaction equation

HRID 2111839 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][C:15]1[N:24]([C:25]2[CH:30]=[CH:29][C:28](O)=[CH:27][CH:26]=2)[C:23](=[O:32])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1>>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:28]2[CH:27]=[CH:26][C:25]([N:24]3[C:23](=[O:32])[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]=[C:15]3[CH3:14])=[CH:30][CH:29]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69889N-benzyl-3-pyrrolidinolHCID 779440HCID 779440, compound

Product 1

HCID 23151307HCID 23151307, compound

Procedure

1-benzyl-3-pyrrolidinol and 2-methyl-3-(4-hydroxyphenyl)-4-(3H) quinazolinone synthesized according to Example 1-(1) and -(2) were etherated by the Mitsunobu reaction according to Example 117-(2), and the target compound was thus obtained.

Workup

  1. custom-(2) were etherated by the Mitsunobu reaction
  2. customthe target compound was thus obtained

Sources & evidence

ORD record
ord-ac79ee93d9d34f87973ab9cabbcafe62
Source dataset
uspto-grants-2009_04
Patent number
US07521455B2

Reaction notes

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