反应详情

6-chloro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-d]pyrimidin-4(3H)-one (300 mg, 1.04 mmol) was dissolved in dry methanol (15 mL) in a current of nitrogen, sodium methoxide (7 mmol) was added and the mixture was heated under reflux for 20 hours. After leaving to cool, acetic acid was added and the solvent was distilled off under reduced pressure. Distilled water was added to the residue, the solid precipitate was filtered off, and the title compound (259 mg, 88%) was thus obtained as a lavender color solid.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureunder reflux for 20 hours
4. customAfter leaving
5. temperatureto cool
6. distillationthe solvent was distilled off under reduced pressure
7. additionDistilled water was added to the residue
8. filtrationthe solid precipitate was filtered off