Fumaric Acid → HCID 68574582, compound

Participants

Reaction Conditions

Reaction Steps

Isobutyl-(piperidin-4-yl)-[(thiazol-4-yl)methyl]-amine (380 mg, 1.50 mmol, 1 eq.) is dissolved in a 1:1 mixture of diethyl ether and dichloromethane. Fumaric acid (191.5 mg, 1.65 mmol, 1.1 eq.) is dissolved in hot anhydrous methanol (1 ml) and then added to the solution of free base. Precipitation occurred upon cooling at 0° C. for 3 days. The precipitate is filtered, rinsed with ether, and dried in a vacuum oven (40° C.) overnight to give the title compound (416 mg, 75%). m/z=254 (M+1); 1H NMR (CD3OD): δ=8.94 (1H, d), 7.44-7.43 (1H, m), 6.68 (2H, s), 3.88 (2H, s), 3.43 (2H, brd), 2.99-2.85 (3H, m) 2.33 (2H, d), 2.04 (2H, brd), 1.83-1.63 (3H, m), 0.87 (6H, d).

Provenance & Evidence