L-Tartaric acid → HCID 68574649, compound

Participants

Reaction Steps

N-(2-Methylpropyl)-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]piperidin-4-amine (0.70 g, 2.49 mmol) and L-tartaric acid (0.37 g, 2.49 mmol) are dissolved in methanol (25 ml). The solution is stirred for 1.5 h and concentrated. The solid is dried in a vacuum oven overnight to yield (1.05 g, 98%) N-(2-methylpropyl)-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]piperidin-4-amine tartrate: mass spectrum (ion spray): m/z=282.2 (M+1); 1H NMR (CD3OD): δ=4.45 (2H, s), 3.77 (2H, s), 3.47 (2H, brd), 3.00-2.91 (2H, m), 2.88-2.79 (1H, m), 2.62 (3H, s), 2.34-2.30 (5H, m), 1.99 (2H, brd), 1.85-1.70 (3H, m), 0.93 (6H, d).

Provenance & Evidence