L-Tartaric acid → HCID 68576497, compound

Participants

Reaction Steps

N-(Cyclopropylmethyl)-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]piperidin-4-amine (1.25 g, 4.46 mmol) and L-Tartaric acid (0.67 g, 4.46 mmol) are dissolved in methanol (25 ml). The solution is stirred for 1.5 h and concentrated. The solid is dried in a vacuum oven overnight to yield (1.86 g, 97%) N-(cyclopropylmethyl)-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]piperidin-4-amine tartrate: mass spectrum (ion spray): m/z=280.2 (M+1); 1H NMR (CD3OD): δ=4.45 (2H, s), 3.87 (2H, s), 3.45 (2H, brs), 3.11-2.93 (3H, m), 2.62 (3H, s), 2.45 (2H, d), 2.32 (3H, s), 2.02 (2H, brd), 1.96-1.76 (2H, m), 0.95-0.85 (1H, m), 0.56-0.49 (2H, m), 0.17-0.10 (2H, m).

Provenance & Evidence