4-Chloro-6-(4-fluorophenyl)pyrimidin-2-amine → N4-[3,5-Difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-(4-fluorophenyl)-pyrimidine-2,4-diamine
Reaction equation
[Cl:20][c:21]1[n:22][c:23]([NH2:34])[n:24][c:25](-[c:27]2[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]2)[cH:26]1.[F:1][c:2]1[cH:3][c:4]([NH2:19])[cH:5][c:6]([F:18])[c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[nH:15][cH:16][cH:17]2>>[F:1][c:2]1[cH:3][c:4]([NH:19][c:21]2[n:22][c:23]([NH2:34])[n:24][c:25](-[c:27]3[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]3)[cH:26]2)[cH:5][c:6]([F:18])[c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[nH:15][cH:16][cH:17]2Participants
3
Sources & evidence
- ORD record
- ord-30a7f2b02d7545908ac42abc0acf18b0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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