HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenyl isocyanate → HCID 135500083, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| Reactant | 3-(2-Amino-4-chlorophenyl)-1,2,4-oxadiazol-5(2H)-one | HCID 136034682 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 135500083 | HCID 135500083 | 63% |
Reaction Steps
3-(2-Amino-4-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one (400 mg, 1.92 mmol) was dissolved in 20 ml dry THF and 3-trifluoromethyl-phenyl-isocyanate (450 mg, 2.40 mmol) was added and the reaction stirred for 16 hours. The solvent was reduced under vacuum and the product recrystallised from ethyl acetate and heptane to yield 480 mg (63%) of off-white crystalline solid (m.p. 246-248; decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07521480B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-06d71198e0ec4e3da5527ee67b1bc718 |
| Source note | uspto-grants-2009_04 |