Sodium Carbonate → (1,1'-Biphenyl)-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

p-Iodo-benzoic acid (4.96 g, 20 mmol), phenyl boronic acid (2.68 g, 22 mmol), Na2CO3 (6.36 g, 60 mmol) and Pd(OAc)2 (44 mg) were dissolved in 80 ml water and heated to 50° C. for 1 hour. Filtered and washed EtOAc, then acidified with 1 M HCl and extracted into EtOAc, dried with Na2SO4, evaporated and recrystallised from EtOAc and heptane to yield 3.9 g of meta-phenyl benzoic acid as a white solid. 2-(3-Biphenyl-3-yl-ureido)-4-chloro-benzoic acid was then prepared according to method E (m.p. 181-183° C.).

Provenance & Evidence