Potassium Carbonate → HCID 68870373, compound

Participants

Reaction Steps

4-[3-(3,4-dihydroisoquinolin-2(1H)-yl)-3-oxopropyl]phenol (155 mg, 0.551 mmol) was dissolved in acetonitrile (10 ml). 2-Bromomethylbenzoic acid methyl ester (126 mg, 0.551 mmol) was added followed by potassium carbonate anhydrous (114 mg, 0.826 mmol). The mixture was heated to reflux overnight and then evaporated to dry. Water and ethyl acetate were added and two phases were separated. The organic phase was dried (magnesium sulphate) and evaporated. Column chromatography of the residue on silica gel using ethyl acetate/heptane (40:60) as eluant gave 135 mg the desired product, yield 57%.

Provenance & Evidence