3-(4-Hydroxyphenyl)propionic acid → HCID 68871483, compound

Participants

Reaction Conditions

Reaction Steps

N-Ethyl-N-(2-pyridin-2-ylethyl)amine (0.5 g, 3.32 mmol) and 3-(4-hydroxyphenyl)-propanoic acid (0.50 g, 3.00 mmol) was dissolved in dimethylformamide (5 ml) and cooled to 0° C. N-[(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate (1.18 g, 3.66 mmol) and diisopropylethylamine (0.90 g, 7.0 mmol) were added and the solution was warmed to room temperature and stirred overnight. EtOAc (15 ml) was added and the organic phase was washed with two portions of sodium hydrogencarbonate (aq, 10 ml). The organic phase was dried MgSO4) and EtOAc was removed by evaporation to give 0.913 gram of N-ethyl-3-(4 hydroxyphenyl)-N-(2-pyridin-2-ylethyl)propanamide (yield 91.9%).

Provenance & Evidence