Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → ethyl (4-amino-3-oxo-3H-isobenzofuran-1-ylidene)-acetate

Participants

Reaction Steps

500 mg (3.1 mmol) 4-amino-isobenzofuran-1,3-dione and 1.13 g (3.1 mmol) (ethoxy-carbonylmethylene)-triphenylphosphorane are dissolved in 5 ml of tetrahydrofuran (THF) and refluxed for 3 h. Then the solvent is eliminated in vacuo. The crude product is purified by column chromatography. The carrier used is silica gel and the eluant used is a mixture of cyclohexane:ethyl acetate (75:25).

Provenance & Evidence