ethyl (4-amino-3-oxo-3H-isobenzofuran-1-ylidene)-acetate → Ethyl (4-amino-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-acetate

Participants

Reaction Steps

120 mg (0.51 mmol) ethyl (4-amino-3-oxo-3H-isobenzofuran-1-ylidene)-acetate are dissolved in 50 ml of methanol and combined with 50 mg palladium on activated charcoal (10% Pd). The reaction mixture is hydrogenated for 3 h at 2 bar H2 pressure and 25° C. Then the catalyst is filtered off and the solvent is eliminated in vacuo.

Provenance & Evidence