HCID 67094887, compound → HCID 67095286, compound

HRID 2112086Notes

Reaction equation

HRID 2112086 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[C:3]=1[C:4]([NH:6][CH:7]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]([O:10]C)=[O:9])=[O:5]>[OH-].[K+]>[NH2:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[C:3]=1[C:4]([NH:6][CH:7]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]([OH:10])=[O:9])=[O:5]

Participants

3

Reactant 1

HCID 67094887HCID 67094887, compound

Product 1

HCID 67095286HCID 67095286, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Conditions

Temperature
50 °C

Procedure

1.04 g (3.03 mmol) methyl 2-(2-amino-6-nitro-benzoylamino)-3-phenyl-propionate are dissolved in 3 ml 20% ethanolic KOH and stirred for 1.5 h at 50° C. Then the solvent is eliminated in vacuo and the crude product is purified by chromatography. The carrier used is silica gel and the eluant used is dichloromethane, to which 15% of a mixture of 90% methanol and 10% saturated aqueous ammonia solution has been added.

Workup

  1. customthe crude product is purified by chromatography
  2. additionto which 15% of a mixture of 90% methanol and 10% saturated aqueous ammonia solution has been added

Sources & evidence

ORD record
ord-988b8044977d4529a54d72e858c57a20
Source dataset
uspto-grants-2009_04
Patent number
US07521457B2

Reaction notes

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