HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-nitrobenzonitrile → 3-Methoxy-4-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-nitrobenzonitrile | HCID 2783399 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Methoxy-4-nitrobenzonitrile | HCID 10899227 | — |
Reaction Steps
25 g (150.504 mmol) 3-fluoro-4-nitrobenzonitrile and 25 g (462.757 mmol) sodium methoxide are dissolved in 125 ml THF at 0° C. This reaction mixture is stirred for 30 min. The reaction mixture is extracted with ethyl acetate and 1 N hydrochloric acid. The organic phase is dried with magnesium sulphate and the solvent is eliminated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07521457B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-b874563b47454ad18f5ab067146f623c |
| Source note | uspto-grants-2009_04 |