HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Dimethyl-7-nitro-2,3-dihydro-isoindol-1-one → 3,3-Dimethyl-7-amino-2,3-dihydro-isoindol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Dimethyl-7-nitro-2,3-dihydro-isoindol-1-one | HCID 67095341 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,3-Dimethyl-7-amino-2,3-dihydro-isoindol-1-one | HCID 67095007 | — |
Reaction Steps
67 mg (0.325 mmol) 3,3-dimethyl-7-nitro-2,3-dihydro-isoindol-1-one are dissolved in 50 ml of methanol and combined with 10 mg palladium on charcoal. The mixture is hydrogenated for 16 h at 4 bar H2 pressure and ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07521457B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-5abc06f3a19d4a38a44e89590cf20fc1 |
| Source note | uspto-grants-2009_04 |