5-Ethynylpyridin-2-amine → [3-(6-Amino-pyridin-3-ylethynyl)-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol

HRID 211215Notes

Reaction equation

HRID 211215 reaction equation
[C:20](#[CH:21])[c:22]1[cH:23][cH:24][c:25]([NH2:28])[n:26][cH:27]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH2:14][OH:15])[cH:13]2)[n:16][cH:17][c:18]3[I:19])[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH2:14][OH:15])[cH:13]2)[n:16][cH:17][c:18]3[C:21]#[C:20][c:22]2[cH:23][cH:24][c:25]([NH2:28])[n:26][cH:27]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 219548275-Ethynylpyridin-2-amineHCID 67001059[5-(4-Chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol

Product 1

HCID 67001053[3-(6-Amino-pyridin-3-ylethynyl)-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol

Sources & evidence

ORD record
ord-586c1919780541898a7942e1c0f346fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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