反应详情

温度

-10 °C

2-(4-Bromophenyl)-2-hydroxyacetic acid (97 g; 0,42 mol) is dissolved in 200 ml of acetone and the solution is cooled to −10° C. At this temperature 23 ml of concentrated sulfuric acid are added dropwise. After the addition is complete the reaction mixture is stirred at −10° C. for further 30 minutes and is subsequently poured into a cooled (0° C.) solution of sodium carbonate (86 g; 0,81 mol) in 800 ml of water. The crystalline 5-(4-bromophenyl)-2,2-dimethyl-1,3-dioxolan-4-one is filtered, washed with ice-cold water and dried in the high vacuum.

1. additionAfter the addition
2. additionis subsequently poured into
3. filtrationThe crystalline 5-(4-bromophenyl)-2,2-dimethyl-1,3-dioxolan-4-one is filtered
4. washwashed with ice-cold water
5. customdried in the high vacuum