HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 131726121, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 294894 | — |
| Reactant | HCID 131726119 | HCID 131726119 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131726121 | HCID 131726121 | — |
Reaction Steps
The compound of Example 8B is dissolved in DMF; 4-tert-butoxycarbonylamino-butanoic acid (1.3 eq) is added, along with 1.2 equivalents of Cs2CO3. The resultant mixture is stirred overnight at ambient temperature. The reaction mixture is partitioned between aqueous phosphoric acid (1N) and ethyl acetate. The organic extract is dried (Na2SO4), filtered, and concentrated in vacuo. The crude material is purified on silica gel using a gradient of ethyl acetate in hexanes to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07521439B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-85fb1667ba9241c6aaf111077250866a |
| Source note | uspto-grants-2009_04 |