Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 22630950 | HCID 22630950 | — |
| Product | HCID 68880263 | HCID 68880263 | 72% |
Reaction Steps
0.52 g (2.77 mmol) 3-quinolin-6-yl-propan-1-ol were dissolved in 5.5 ml thionylchloride and heated to 70° C. for 50 minutes. Water and aqueous sodium hydrogencarbonate were added and the mixture was extracted three times with DCM. The combined organic layers were washed with brine, dried over MgSO4 and concentrated in vacuo to give 0.41 g (72%) of a brown oil. MS(ISP): 206.2 [MH]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07524823B2 |
|---|
| Source dataset | uspto-grants-2009_04 |
|---|
| ORD ID | ord-0953cbcec5e94095af081e80f3820c9b |
|---|
| Source note | uspto-grants-2009_04 |
|---|
