4-Acetylbenzoic Acid → 4-Acetyl-N-((5S)-5-amino-5-carbamoylpentyl)benzamide

HRID 2112419Notes

Reaction equation

HRID 2112419 reaction equation
[NH2:1][C@@H:2]([CH2:6][CH2:7][CH2:8][CH2:9][NH:10]C(=O)CCC(=O)C1C=CC=CC=1)[C:3]([NH2:5])=[O:4].[C:23]([C:26]1[CH:34]=[CH:33][C:29]([C:30]([OH:32])=O)=[CH:28][CH:27]=1)(=[O:25])[CH3:24]>>[C:23]([C:26]1[CH:27]=[CH:28][C:29]([C:30]([NH:10][CH2:9][CH2:8][CH2:7][CH2:6][C@H:2]([NH2:1])[C:3](=[O:4])[NH2:5])=[O:32])=[CH:33][CH:34]=1)(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 114704-Acetylbenzoic AcidHCID 11220467(2S)-2-Amino-6-(4-oxo-4-phenylbutyrylamino)hexanoic acid amide

Product 1

HCID 111738334-Acetyl-N-((5S)-5-amino-5-carbamoylpentyl)benzamide

Procedure

1.65 g of the title compound was prepared as described for (2S)-2-amino-6-(4-oxo-4-phenylbutyrylamino)hexanoic acid amide, using 4-acetylbenzoic acid instead of benzoylpropionic acid.

Sources & evidence

ORD record
ord-8172ddf56dfb4828b3bcdece682d6aab
Source dataset
uspto-grants-2009_04
Patent number
US07524813B2

Reaction notes

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