Lawesson's reagent → HCID 57642346, compound

HRID 2112499Notes

Reaction equation

HRID 2112499 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([F:29])[C:17]([O:19][CH2:20][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:40])=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([F:29])[C:17]([O:19][CH2:20][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[CH:18][C:13]=2[NH:12][C:11](=[S:40])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 57642355HCID 57642355, compound

Product 1

HCID 57642346HCID 57642346, compound

Procedure

5-(2-chlorophenyl)-1,3-dihydro-7-fluoro-8-(3-(4-morpholinyl)propoxy)-2H-1,4-benzodiazepin-2-thione (IIi) was prepared by reacting 0.0053 moles of 5-(2-chlorophenyl)-1,3-dihydro-7-fluoro-8-(3-(4-morpholinyl)propoxy)-2H-1,4-benzodiazepin-2-one (lactam Ii) with Lawesson's reagent in a manner analogous to Example 38.

Sources & evidence

ORD record
ord-8a05fcc41c8042b990ca1fad93428bd9
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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