Lawesson's reagent → HCID 57642362, compound

HRID 2112500Notes

Reaction equation

HRID 2112500 reaction equation
[Br:1][C:2]1[C:3]([O:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[CH:4][C:5]2[NH:11][C:10](=O)[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:6]=2[CH:20]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:40])=CC=1>>[Br:1][C:2]1[C:3]([O:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[CH:4][C:5]2[NH:11][C:10](=[S:40])[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:6]=2[CH:20]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 57642345HCID 57642345, compound

Product 1

HCID 57642362HCID 57642362, compound

Procedure

7-bromo-5-(2-chlorophenyl)-1,3-dihydro-8-(3-(4-morpholinyl)propoxy)-2H-1,4benzodiazepin-2-thione (IIj) was prepared by reacting 0.0011 moles of 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-8-(3-(4-morpholinyl)propoxy)-2H-1,4-benzodiazepin-2-one (Ij) with Lawesson's reagent in a manner analogous to Example 38. MH+/Z=508.

Sources & evidence

ORD record
ord-c9f64e2634584394ba6dbf2b9efbf8ae
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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