Lawesson's reagent → HCID 57642359, compound

HRID 2112502Notes

Reaction equation

HRID 2112502 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:24]#[N:25])[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:36])=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:24]#[N:25])[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[CH:18][C:13]=2[NH:12][C:11](=[S:36])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 57642336HCID 57642336, compound

Product 1

HCID 57642359HCID 57642359, compound

Procedure

5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-methoxyethoxy-2H-1,4-benzodiazepin-2-thione (IIm) was prepared by reacting 0.00081 moles of 5-(2-chlorophenyl)-7-cyano-1,3-dihydro-8-methoxyethoxy-2H-1,4-benzodiazepin-2-one (Im) with Lawesson's reagent in a manner analogous to Example 38. MH+/Z=386.

Sources & evidence

ORD record
ord-4a9d69aff34640b993fbbc628484f2c1
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

Loading…