Lawesson's reagent → 5-(2-chlorophenyl)-1,3-dihydro-7,8-dimethyl-2H-1,4-benzodiazepin-2-thione

HRID 2112505Notes

Reaction equation

HRID 2112505 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([CH3:20])[C:17]([CH3:19])=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:31])=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([CH3:20])[C:17]([CH3:19])=[CH:18][C:13]=2[NH:12][C:11](=[S:31])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 576423605-(2-chlorophenyl)-1,3-dihydro-7,8-dimethyl-2H-1,4-benzodiazepin-2-one

Product 1

HCID 576423635-(2-chlorophenyl)-1,3-dihydro-7,8-dimethyl-2H-1,4-benzodiazepin-2-thione

Procedure

5-(2-chlorophenyl)-1,3-dihydro-7,8-dimethyl-2H-1,4-benzodiazepin-2-thione (Iw) was prepared by reacting 0.0006 moles of 5-(2-chlorophenyl)-1,3-dihydro-7,8-dimethyl-2H-1,4-benzodiazepin-2-one (Iw) with Lawesson's reagent in a manner analogous to Example 38.

Sources & evidence

ORD record
ord-08eb7b8525914a6d810b374ff0f8f66d
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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