Lawesson's reagent → 5-(2-chlorophenyl)-1,3-dihydro-8-methoxy-7-methyl-2H-1,4-benzodiazepin-2-thione

HRID 2112506Notes

Reaction equation

HRID 2112506 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([CH3:21])[C:17]([O:19][CH3:20])=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:32])=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([CH3:21])[C:17]([O:19][CH3:20])=[CH:18][C:13]=2[NH:12][C:11](=[S:32])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 576423255-(2-chlorophenyl)-1,3-dihydro-8-methoxy-7-methyl-2H-1,4-benzodiazepin-2-one

Product 1

HCID 576423175-(2-chlorophenyl)-1,3-dihydro-8-methoxy-7-methyl-2H-1,4-benzodiazepin-2-thione

Procedure

5-(2-chlorophenyl)-1,3-dihydro-8-methoxy-7-methyl-2H-1,4-benzodiazepin-2-thione (IIz) was prepared by reacting 0.0064 moles of 5-(2-chlorophenyl)-1,3-dihydro-8-methoxy-7-methyl-2H-1,4-benzodiazepin-2-one (Iz) with Lawesson's reagent in a manner analogous to Example 38.

Sources & evidence

ORD record
ord-0046d02180504248bbc1039f32c9f640
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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