HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminumhydride → HCID 178486441, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | (2-Amino-5-fluoro-4-methoxyphenyl)(2-chlorophenyl)methanone | HCID 44182528 | — |
| Reactant | 1-Allyl-5-chloro-3-methyl-1H-pyrazol-4-amine | HCID 57642344 | — |
| Reactant | HCID 178456643 | HCID 178456643 | — |
| Product | HCID 178486441 | HCID 178486441 | — |
Reaction Steps
5-(2-chlorophenyl)-1,2-dihydro-7-fluoro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVa) was prepared by reacting 0.0014 moles of (2-amino-5-fluoro-4-methoxyphenyl)(2-chlorophenyl)-methanone (Xa) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 5-(2-chlorophenyl)-1,2-dihydro-7-fluoro-8-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3 ,4-b][1,4]benzodiazepine (XIVa) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=357.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524840B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-5bd038e70d654695acf3ad2089b2a441 |
| Source note | uspto-grants-2009_04 |