Diisobutylaluminumhydride → 7-chloro-5-(2-chlorophenyl)-8-methoxy-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine

Participants

Role	Name	HCID	Charge
Reactant	Diisobutylaluminumhydride	HCID 21225700	—
Reactant	1-Allyl-5-chloro-3-methyl-1H-pyrazol-4-amine	HCID 57642344	—
Reactant	(2-Amino-5-chloro-4-methoxyphenyl)-(2-chlorophenyl)-methanone	HCID 57642381	—
Reactant	7-chloro-5-(2-chlorophenyl)-8-methoxy-3-methyl-1-prop-2-enyl-2H-pyrazolo[3,4-b][1,4]benzodiazepine	HCID 178456642	—
Product	7-chloro-5-(2-chlorophenyl)-8-methoxy-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine	HCID 178486422	—

Reaction Steps

7-chloro-5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVcc) was prepared by reacting 0.0023 moles of (2-amino-5-chloro-4-methoxyphenyl)-(2-chlorophenyl)-methanone (Xcc) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 7-chloro-5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVcc) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=373.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07524840B2
Source dataset	uspto-grants-2009_04
ORD ID	ord-9c207f0b3f6442c7b37a9dd01bdd5dcc
Source note	uspto-grants-2009_04